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Browse these ideas available for licensing that have the potential to improve lives while creating jobs to support and grow the region.

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 are listed as non-confidential technical summaries.

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Treating Neurological Diseases, Autoimmune Disorders, and Muscular Disorders Using Rev-erb Modulators


Rev-erbs are members of the nuclear receptor super-family of proteins. They regulate transcription for proteins involved in a number of physiological processes. As such, they represent an attractive drug target. Rev-erb agonists have potential in a number of therapeutic settings, including neurological diseases, autoimmune disorders, and muscular disorders. Currently, there are no modulators of rev-erb on the market.


Researchers at Saint Louis University have developed a new chemical series of rev-erb agonists. They have compiled in vitro and a limited amount of in vivo data to demonstrate the efficacy of these new compounds.


The potential advantages of this technology over existing solutions include:

  • Increase pharmocokinetic properties
  • Increase potency of therapies

Potential applications of this technology include treating various diseases and disorders such as:

  • Neurological diseases, especially those related to anxiety disorders
  • Autoimmune disorders
  • Muscular disorders

Additional Details


St. Louis University

Intellectual Property Protection

Pending Patent

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