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Repurposed FDA-Approved Compounds for the Treatment of SARS-CoV2 / COVID-19

Innovation
Using in silico protein-ligand structure prediction algorithms developed at the University of Missouri (MU), researchers identified multiple FDA-approved drugs with potential to interfere with four essential SARS-CoV2 viral proteins (nsp13 helicase, PLpro, 3CLpro, and NSP12). Repurposing these FDA-approved drugs provides a unique opportunity to respond quickly to the COVID-19 pandemic.

Background
As of May, 2020, the Coronavirus Disease (COVID‐19) pandemic has, in its first 6 months, claimed ~300,000 lives, and has caused more than 4.18 million infections globally. COVID‐19 results from infection by severe acute respiratory syndrome coronavirus 2 (SARS CoV‐2).

Due to their essential roles, several viral proteins have been identified as attractive drug targets. Among them, nsp13 helicase is essential in viral replication; papain-like protease (PLpro) and 3C-like protease (3CLpro) are cysteine proteases that process the viral polyprotein; and nsp12 RdRp catalyzes the replication of the viral RNA genome.

MU researchers have used their novel protein-ligand structure prediction algorithm and in silico screening methods to identify multiple FDA-approved drugs with therapeutic potential for COVID-19.

Applications
- Treatment of SARS-CoV2 / COVID-19

Advantages
- FDA-approved small molecule inhibitors, potential for expedited approval for COVID-19
- >30 candidate therapeutics targeting four essential viral proteins
State of Development
Preclinical

Additional Details

Owner

University of Missouri-Columbia

Intellectual Property Protection

Pending Patent



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