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Modulation of enzymes for the treatment of influenza

Influenza virus continues to cause tremendous morbidity and mortality on an annual basis. While vaccines exist to help prevent infection, there are only a handful of drugs approved for treating the infected individual. Moreover, the virus has evolved, in many cases, to become resistant to these treatments. The current discovery identifies sphingosine-1-phosphate pathway as critical for virus replication. Blocking sphingosine kinase activity or over expressing sphingosine 1-phosphate lyase strongly inhibited virus propagation. Therefore, modulation of this pathway could lead to new points of pharmaceutical intervention.

APPLICATIONS:
-Inhibit influenza virus replication

ADVANTAGES:
-Fresh target for pharmaceutical intervention
-Complements current drug mechanisms of action 

STAGE OF RESEARCH:
-Preclinical

Additional Details

Owner

University of Missouri - Columbia

Intellectual Property Protection

Pending Patent



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