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Use of Glycoproteins in Contraception and the Diagnosis of Human Infertility

To fertilize the human egg (oocyte), human sperm must first bind on the surface of the oocyte. The sperm binds to the oocytes via both the carbohydrate and protein portion of the glycoprotein. A human glycoprotein that is the equivalent to that on the oocyte can be used as a contraceptive agent by acting as a decoy. The carbohydrate sequences from these glycoproteins can also be used as agents, either singly or conjugated to polymers or other supports, for multiple uses including methods in the field of human infertility diagnosis. This discovery takes advantage of the unique species specific interactions between human sperm and oocytes.

POTENTIAL AREAS OF APPLICATION:
-Large potential in the natural contraceptive market
-Species specific sperm binding assays

MAIN ADVANTAGES OF INVENTION:
-Uses newly identified, species-specific oligosaccharides found on oocytes
-Only contraceptive agent that targets the mechanisms for the induction of the acrosome reaction 

STAGE OF DEVELOPMENT:
-Preclinical 

Additional Details

Owner

University of Missouri - Columbia

Intellectual Property Protection

Pending Patent



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