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Engineered regulatory T Cells for the treatment of GVHD and inflammatory diseases

  • A novel cell based therapy to combat disordered inflammation. Using a novel method, CD4+ and CD8+ regulatory T cells have been engineered to over express both FOXP3 and Helios without suppression of either product. Efficacy of the eTregs has been shown in vitro and in a humanized model of graft versus host disease (GVHD)

  • Benefit

    • The CD4+ and CD8+ eTregs exhibit stable expression, with about 98% of FOXP3+Helios+ cells retaining high FOXP3 and Helios expression 21 days post-transduction and 12 days in vivo in mice
    • Can separate CD4+ and CD8+ cells if desired
    • The novel method produces larger quantities of eTregs more rapidly by eliminating the need to isolate and expand populations of naturally occurring Tregs
    • First reported generation of CD8+ Tregs with suppressive activity

    Market Application

    • Biologic for the treatment of GVHD in organ and stem cell transplant patients
    • Biologic for the treatment of diseases in which it is desirable to reduce inflammatory immune responses. Examples would include type I diabetes, multiple sclerosis, allograft/transplant rejection, inflammatory bowel disease, lupus, rheumatoid arthritis, and other chronic inflammatory diseases

    Publications

    Co-expression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells. A. Seng, et al; Blood Advances, Vol 4 (7), 1325-1339
 

Additional Details

Owner

Childrens Mercy Hospital and Kansas University

Intellectual Property Protection

Patent Issued



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