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Decrease Inflammation in Early Lactation Dairy Cattle to Boost Milk Yield and Decrease Culling

Collaborative research between Kansas State University and Iowa State University has shown that the administration of non-steroidal anti-inflammatory drugs (NSAID) to early lactating dairy cattle increases whole-lactation yields of milk and decreases the rate of culling. There is growing evidence that inflammation is common in early lactation dairy cows. Although some degree of inflammation is probably necessary for immune system activation, excess inflammation has been linked to a number of negative outcomes. In particular, inflammation in early lactation has been repeatedly linked to decreased whole-lactation milk production. The use of anti-inflammatory treatment in early lactation to increase milk production has been previously described. However, milk produced by cows while being treated with anti-inflammatory drugs must be disposed of and these dairy cattle are often culled. What is needed is a short-term treatment that increases milk yield and reduces culling.

This patent pending technology is for a method of treating dairy cattle with one or more NSAIDs (specifically, sodium salicylate and meloxicam) during a narrow window of time (treatment starting at or about 12 - 36 hours after parturition, and continuing for about 1 to 3 days) in order to increase whole-lactation milk production and/or increase retention (decrease culling) in the herd. The inventors demonstrated that whole-lactation (305-day mature equivalent) yields of milk and milk protein were significantly increased by both meloxicam and sodium salicylate treatments, with 6 - 9% increases observed in these initial dairy cattle studies. Milk fat yield was not significantly different across treatments. Weekly milk yield analysis resulted in a similar 10 - 12% increase in milk yield after meloxicam and sodium salicylate treatment, with an effect first appearing in week 4 of lactation and remaining throughout the remainder of the 44-week lactation. The researchers were able to also show that cows were removed from herd at a slower rate after parturition with administration of meloxicam.

ADVANTAGES:
-Inexpensive
-Administration of treatment over a narrow window of time
-Long term benefit over the whole lactation period
-Less culling

APPLICATIONS:
-Increase milk yield
-Decrease culling

PATENT STATUS:
-Provisional patent application was filed in September 2014.

Additional Details

Owner

Kansas State University

Intellectual Property Protection

Pending Patent



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