Skip To The Main Content

Browse these ideas available for licensing that have the potential to improve lives while creating jobs to support and grow the region.


All ideas
are listed as non-confidential technical summaries.

Ideas were generated by academic institutions, entrepreneurs, and corporations.

Ideas from our research institution partners can be reviewed by following the web links to their database.

Highlighted ideas from our partners are featured separately and organized by category. All listings are updated as new technology opportunities become available..

For assistance in connecting with, or attaining further information on any of these technologies, please contact us.

Broad Spectrum Resistance to Multiple Viruses in Plants

Current methods to provide resistance to RNA viruses infecting wheat focus on targeting a plant gene to provide selective resistance against one specific virus. This method fails to provide the necessary long term efficacy needed to control viral diseases that result in significant yield losses, often times as high as 20-25%. Researchers at Kansas State University and USDA-ARS have developed a new method for targeting a virus gene to provide broad spectrum resistance to multiple viruses in wheat, and potentially other crops infected by RNA viruses.

This method is built on the premise that RNA viruses use host genes to complete their life cycles; therefore, when a virus enters a cell, the protein coat is removed and host proteins are then used to translate and replicate the viral RNA. With this in mind, our researchers have modified the plant so that it can limit the expression of two critical proteins used in this process. By utilizing hairpin RNA structures derived from the two critical wheat proteins, researchers have been able to induce a plant RNA protection system inside the cell that targets the RNA of these two plant genes. By reducing the expression of the wheat proteins via utilization of the siRNA, replication of the virus is prevented and resistance is created. To date, K-State and USDA researchers have produced transgenic wheat lines for each construct that are in the 5th generation, as shown below, and research shows complete resistance to both WSMV and TriMV, with potential for other viruses.

ADVANTAGES:
-Targets virus gene replication, ultimately affecting the lifecycle
-Broadens protection to multiple viruses, even those already with a host-virus system
-Possible applicability in all cereal crops, as well as in other plants both monocot and dicots

APPLICATIONS:
-Wheat production and disease resistance development
-Private and public variety development
-Development of virus resistant cereals and other crops

PATENT STATUS:
-US Patent Application #14/494,661 filed on September 24, 2014

Additional Details

Owner

Kansas State University

Intellectual Property Protection

Pending Patent



Interested? Request More Information