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An mRNA Platform for Cell-Specific Protein Translation

Innovation
Inventors at the University of Missouri (MU) have developed an mRNA platform for cell-specific protein expression. This novel strategy, which can be used alone or in combination with additional measures, takes advantage of intrinsic cell- and tissue-specific attributes to ensure the mRNA delivered is translated into protein only in targeted cells and tissues, enabling an enhanced level of control in comparison to alternative methods.

Background
Cell- and tissue-specific gene expression occurs biologically as the result of incredibly complex sets of interactions, including those that occur between DNA, RNA, and proteins, and the historical developmental path each cell or tissue has experienced. In research and in therapeutic applications the ability to artificially control cell- and tissue-specific gene expression is very attractive, as it offers a valuable tool to interrogate biological systems and potentially more effectively treat disease. While many approaches have been developed, including tissue-specific promoters, conditional expression systems, and others, invariably off-target gene expression occurs.

MU inventors have developed a novel mRNA design platform, which can be used alone or in combination with other approaches, that offers improved control over gene expression for research and therapeutic applications.

Applications
- Therapeutic: Including mRNA-based vaccines and gene therapy.
- Diagnostics: Cell- and tissue-specific imaging
- Research: Cell- and tissue-specific gene expression

Advantages
- Decreased off-target effects
- Enhanced target specificity for diagnosis and treatment

Additional Details

Owner

University of Missouri

Intellectual Property Protection

Pending Patent



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